Calculate interval AUC of general form

It calculates interval AUC of general form. This is useful for pharmacodynamic data.

Usage

gIntAUC(x, y, t1, t2, Outer = "NEAREST")

Arguments

x: vector values of independent variable, usually time
y: vector values of dependent variable, usually concentration
t1: start time for AUC
t2: end time for AUC
Outer: indicates how to do the out of x range point

Details

This calculates an interval (partial) AUC (from t1 to t2) with the given series of x and y. If t1 and/or t2 cannot be found within x vector, it interpolates. If t1 and/or t2 are out of x range, it uses the nearest value. For concentration data, use IntAUC.

Value

return interval AUC value (scalar)

Author

Kyun-Seop Bae <[email protected]>

Examples

gIntAUC(Theoph[Theoph$Subject==1, "Time"], Theoph[Theoph$Subject==1, "conc"], t1=0.5, t2=11)
#> [1] 84.08191