Convert pharmacokinetic parameters for one compartment model — OneComp_Volume

Calculate pharmacokinetic parameters with volume of distribution (V1) and clearance (Cl1)

Usage

OneComp_Volume_Clearance(V1,Cl1,V1.sd=NA,Cl1.sd=NA,
        covar=c(V1Cl1=NA),...)

Arguments

V1: The volume of distribution of compartment 1
Cl1: Clearance from compartment 1
V1.sd: standard error of V1
Cl1.sd: standard error of Cl1
covar: covariances among parameters
...: arguments to be passed to methods

References

http://www.nonmemcourse.com/convert.xls

Gabrielsson and Weiner(2006) Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Swedish Academy of Pharmaceutical Sciences.

Examples

OneComp_Volume_Clearance(V1=8,Cl1=4,V1.sd=0.01,Cl1.sd=0.01)
#>         Parameter Estimate     Std.err
#> Vdss         Vdss 8.000000 0.010000000
#> V1             V1 8.000000 0.010000000
#> Cl1           Cl1 4.000000 0.010000000
#> k10           k10 0.500000 0.001397542
#> alpha       alpha 0.500000 0.001397542
#> t_alpha   t_alpha 1.386294 0.003874811
#> True_A     True_A 0.125000 0.001562500
#> Frac_A     Frac_A 1.000000 0.000000000