Convert pharmacokinetic parameters for one compartment model

Calculate pharmacokinetic parameters with volume of distribution(V1) and parameter (alpha) in the model "Aexp(-alpha)"

Usage

OneComp_Volume_Exponent(V1,alpha,V1.sd=NA,alpha.sd=NA,
         covar=c(V1alpha=NA),...)

Arguments

V1

The volume of distribution of compartment 1

alpha

parameter in one compartment model "Aexp(-alpha)"

V1.sd

standard error of V1

alpha.sd

standard error of A

covar

covariances among parameters

...

arguments to be passed to methods

References

http://www.nonmemcourse.com/convert.xls

Examples

OneComp_Volume_Exponent(V1=8,alpha=0.5,V1.sd=0.01,alpha.sd=0.001)
#>         Parameter Estimate     Std.err
#> Vdss         Vdss 8.000000 0.010000000
#> V1             V1 8.000000 0.010000000
#> Cl1           Cl1 4.000000 0.009433981
#> k10           k10 0.500000 0.001000000
#> alpha       alpha 0.500000 0.001000000
#> t_alpha   t_alpha 1.386294 0.002772589
#> True_A     True_A 0.125000 0.000156250
#> Frac_A     Frac_A 1.000000 0.000000000