Convert pharmacokinetic parameters for one compartment model — OneComp_Volume

Calculate pharmacokinetic parameters with volume of distribution (V1) and elimination rate constant (k10)

Usage

OneComp_Volume_RateConstant(V1,k10,
             V1.sd=NA,k10.sd=NA,covar=c(V1k10=0),...)

Arguments

V1: The volume of distribution of compartment 1
k10: elimination rate constant
V1.sd: standard error of V1
k10.sd: standard error of k10
covar: covariances among parameters
...: arguments to be passed to methods

References

http://www.nonmemcourse.com/convert.xls

Examples

OneComp_Volume_RateConstant(V1=8,k10=0.5,V1.sd=0.01,k10.sd=0.002)
#>         Parameter Estimate     Std.err
#> Vdss         Vdss 8.000000 0.010000000
#> V1             V1 8.000000 0.010000000
#> Cl1           Cl1 4.000000 0.016763055
#> k10           k10 0.500000 0.002000000
#> alpha       alpha 0.500000 0.002000000
#> t_alpha   t_alpha 1.386294 0.005545177
#> True_A     True_A 0.125000 0.000156250
#> Frac_A     Frac_A 1.000000 0.000000000