Convert pharmacokinetic parameters for three compartment model — ThreeComp_Volume_Clearance

Calculate pharmacokinetic parameters with volume of distributions (Vd and V1), clearance (Cl1) and half-lives (t_alpha, t_beta, and t_gamma)

Usage

ThreeComp_Volume_Clearance_HalfLife(V1,Vd,Cl1,t_alpha,t_beta,t_gamma,
 V1.sd=NA,Vd.sd=NA,Cl1.sd=NA,t_alpha.sd=NA,t_beta.sd=NA,t_gamma.sd=NA,
 covar=c(V1Vd=NA,V1Cl1=NA,V1talpha=NA,V1tbeta=NA,V1tgamma=NA,VdCl1=NA,
   Vdtalpha=NA,Vdtbeta=NA,Vdtgamma=NA,Cl1talpha=NA,Cl1tbeta=NA,
   Cl1tgamma=NA,talphatbeta=NA,talphatgamma=NA,tbetatgamma=NA),...)

Arguments

V1: The volume of distribution of compartment 1
Vd: Total volume of distributions
Cl1: Clearance from compartment 1
t_alpha: half life of compartment 1
t_beta: half life of compartment 2
t_gamma: half life of compartment 3
V1.sd: standard error of V1
Vd.sd: standard error of Vd
Cl1.sd: standard error of Cl1
t_alpha.sd: standard error of t_alpha
t_beta.sd: standard error of t_beta
t_gamma.sd: standard error of t_gamma
covar: covariances among parameters
...: arguments to be passed to methods

References

http://www.nonmemcourse.com/convert.xls

Examples

ThreeComp_Volume_Clearance_HalfLife(V1=5,Vd=1110,Cl1=3,
t_alpha=1.142,t_beta=52.2,t_gamma=931, V1.sd=0.01,Vd.sd=20,Cl1.sd=0.01,
t_alpha.sd=0.002,t_beta.sd=0.5,t_gamma.sd=5.6)
#>         Parameter      Estimate      Std.err
#> Vdss         Vdss  1.110000e+03 2.000000e+01
#> V1             V1  5.000000e+00 1.000000e-02
#> V2             V2 -1.333397e+02 5.823992e+00
#> V3             V3  1.238340e+03 2.511865e+01
#> Cl1           Cl1  3.000000e+00 1.000000e-02
#> Cl2           Cl2 -1.259114e+00 4.141903e-02
#> Cl3           Cl3  1.311515e+00 3.935037e-02
#> k10           k10  6.000000e-01 2.332381e-03
#> k12           k12 -2.518228e-01 8.389653e-03
#> k21           k21  9.442901e-03 1.264291e-02
#> k13           k13  2.623030e-01 7.907486e-03
#> k31           k31  1.059091e-03 1.268215e-05
#> alpha       alpha  6.069590e-01 1.062975e-03
#> beta         beta  1.327868e-02 1.271904e-04
#> gamma       gamma  7.445190e-04 4.478310e-06
#> t_alpha   t_alpha  1.142000e+00 2.000000e-03
#> t_beta     t_beta  5.220000e+01 5.000000e-01
#> t_gamma   t_gamma  9.310000e+02 5.600000e+00
#> True_A     True_A  2.011878e-01 4.104548e-04
#> True_B     True_B -1.259773e-03 3.134049e-05
#> True_C     True_C  7.202236e-05 1.641550e-06
#> Frac_A     Frac_A  1.005939e+00 1.478805e-04
#> Frac_B     Frac_B -6.298866e-03 1.533634e-04
#> Frac_C     Frac_C  3.601118e-04 8.226524e-06