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Convert pharmacokinetic parameters for three compartment model

ThreeComp_Volume_Exponent.Rd

Calculate pharmacokinetic parameters with volume of distribution(V1), transfer rate constant (k12 and k31), and parameters (alpha, beta and gamma) in the model "Aexp(-alpha)+Bexp(-beta)+Cexp(-gamma)"

Usage

ThreeComp_Volume_Exponent(V1,alpha,beta,gamma,k21,k31,
 V1.sd=NA,alpha.sd=NA,beta.sd=NA,gamma.sd=NA,k21.sd=NA,k31.sd=NA,
 covar=c(V1alpha=NA,V1beta=NA,V1gamma=NA,V1k21=NA,V1k31=NA,
   alphabeta=NA,alphagamma=NA,alphak21=NA,alphak31=NA,
   betagamma=NA,betak21=NA,betak31=NA,gammak21=NA,gammak31=NA,
   k21k31=NA),...)

Arguments

V1

The volume of distribution of compartment 1

alpha

parameter in one compartment model "Aexp(-alpha)"

beta

parameter in two compartment model "Aexp(-alpha)+Bexp(-beta)"

gamma

parameter in three compartment model "Aexp(-alpha)+Bexp(-beta)+Cexp(-gamma)"

k21

transfer rate constants from compartment 2 to compartment 1

k31

transfer rate constants from compartment 3 to compartment 1

V1.sd

standard error of V1

alpha.sd

standard error of alpha

beta.sd

standard error of beta

gamma.sd

standard error of gamma

k21.sd

standard error of k21

k31.sd

standard error of k31

covar

covariances among parameters

...

arguments to be passed to methods

References

http://www.nonmemcourse.com/convert.xls

Examples

ThreeComp_Volume_Exponent(V1=10,alpha=0.6, beta=0.013, gamma=0.00074,
   k21=0.02, k31=0.001, V1.sd=0.01,alpha.sd=0.01,beta.sd=0.00005,
   gamma.sd=0.000002, k21.sd=0.0006,k31.sd=0.0000005)
#>         Parameter     Estimate      Std.err
#> Vdss         Vdss 1.096510e+03 3.489726e+01
#> V1             V1 1.000000e+01 1.000000e-02
#> V2             V2 1.028889e+02 3.150367e+00
#> V3             V3 9.836211e+02 3.619794e+01
#> Cl1           Cl1 2.886000e+00 1.000208e-01
#> Cl2           Cl2 2.057779e+00 1.180803e-01
#> Cl3           Cl3 9.836211e-01 3.621340e-02
#> k10           k10 2.886000e-01 9.997919e-03
#> k12           k12 2.057779e-01 1.180624e-02
#> k21           k21 2.000000e-02 6.000000e-04
#> k13           k13 9.836211e-02 3.620003e-03
#> k31           k31 1.000000e-03 5.000000e-07
#> alpha       alpha 6.000000e-01 1.000000e-02
#> beta         beta 1.300000e-02 5.000000e-05
#> gamma       gamma 7.400000e-04 2.000000e-06
#> t_alpha   t_alpha 1.155245e+00 1.925409e-02
#> t_beta     t_beta 5.331901e+01 2.050731e-01
#> t_gamma   t_gamma 9.366854e+02 2.531582e+00
#> True_A     True_A 9.876463e-02 1.438959e-04
#> True_B     True_B 1.167215e-03 1.023345e-04
#> True_C     True_C 6.815910e-05 2.484298e-06
#> Frac_A     Frac_A 9.876463e-01 1.046498e-03
#> Frac_B     Frac_B 1.167215e-02 1.023279e-03
#> Frac_C     Frac_C 6.815910e-04 2.483363e-05