Convert pharmacokinetic parameters for three compartment model

Calculate pharmacokinetic parameters with volume of distribution (V1), elimination rate constant (k10), and transter rate constants (k12, k13, k21, and k31)

Usage

ThreeComp_Volume_RateConstant(V1,k10,k12,k13,k21,k31,
 V1.sd=NA,k10.sd=NA,k12.sd=NA,
 k13.sd=NA,k21.sd=NA,k31.sd=NA,covar=c(V1k10=NA,V1k12=NA,V1k13=NA,
   V1k21=NA,V1k31=NA,k10k12=NA,k10k13=NA,k10k21=NA,k10k31=NA,
   k12k13=NA,k12k21=NA,k12k31=NA,k13k21=NA,k13k31=NA,k21k31=NA),...)

Arguments

V1

The volume of distribution of compartment 1

k10

elimination rate constant

k12

transfer rate constants from compartment 1 to compartment 2

k13

transfer rate constants from compartment 1 to compartment 3

k21

transfer rate constants from compartment 2 to compartment 1

k31

transfer rate constants from compartment 3 to compartment 1

V1.sd

standard error of V1

k10.sd

standard error of k10

k12.sd

standard error of k12

k13.sd

standard error of k13

k21.sd

standard error of k21

k31.sd

standard error of k31

covar

covariances among parameters

...

arguments to be passed to methods

References

http://www.nonmemcourse.com/convert.xls

Examples

ThreeComp_Volume_RateConstant(V1=10,k10=0.3,k12=0.2,k13=0.1,k21=0.02,
         k31=0.001,V1.sd=0.1,k10.sd=0.002,k12.sd=0.001,
         k13.sd=0.0005,k21.sd=0.0005,k31.sd=0.000005)
#>         Parameter     Estimate      Std.err
#> Vdss         Vdss 1.110000e+03 1.340560e+01
#> V1             V1 1.000000e+01 1.000000e-01
#> V2             V2 1.000000e+02 2.738613e+00
#> V3             V3 1.000000e+03 1.224745e+01
#> Cl1           Cl1 3.000000e+00 3.605551e-02
#> Cl2           Cl2 2.000000e+00 2.236068e-02
#> Cl3           Cl3 1.000000e+00 1.118034e-02
#> k10           k10 3.000000e-01 2.000000e-03
#> k12           k12 2.000000e-01 1.000000e-03
#> k21           k21 2.000000e-02 5.000000e-04
#> k13           k13 1.000000e-01 5.000000e-04
#> k31           k31 1.000000e-03 5.000000e-06
#> alpha       alpha 6.069796e-01 2.286096e-03
#> beta         beta 1.327584e-02 3.273143e-04
#> gamma       gamma 7.445863e-04 4.029127e-06
#> t_alpha   t_alpha 1.141961e+00 4.301024e-03
#> t_beta     t_beta 5.221116e+01 1.287260e+00
#> t_gamma   t_gamma 9.309159e+02 5.037399e+00
#> True_A     True_A 9.882577e-02 9.887344e-04
#> True_B     True_B 1.109493e-03 3.255193e-05
#> True_C     True_C 6.473832e-05 9.911606e-07
#> Frac_A     Frac_A 9.882577e-01 3.070102e-04
#> Frac_B     Frac_B 1.109493e-02 3.060279e-04
#> Frac_C     Frac_C 6.473832e-04 7.505294e-06