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Convert pharmacokinetic parameters for two compartment model

TwoComp_Volume_Clearance.Rd

Calculate pharmacokinetic parameters with volume of distributions (V1 and V2) and clearances (Cl1 and Cl2)

Usage

TwoComp_Volume_Clearance(V1,V2,Cl1,Cl2,
                  V1.sd=NA,V2.sd=NA,Cl1.sd=NA,Cl2.sd=NA,
                  covar=c(V1V2=0,V1Cl1=0,V1Cl2=0,
                    V2Cl1=0,V2Cl2=0,Cl1Cl2=0),...)

Arguments

V1

The volume of distribution of compartment 1

V2

The volume of distribution of compartment 2

Cl1

Clearance from compartment 1

Cl2

Clearance from compartment 2

V1.sd

standard error of V1

V2.sd

standard error of V2

Cl1.sd

standard error of Cl1

Cl2.sd

standard error of Cl2

covar

covariances among parameters

...

arguments to be passed to methods

References

http://www.nonmemcourse.com/convert.xls

Examples

TwoComp_Volume_Clearance(V1=5,V2=50,Cl1=3.5,Cl2=2.5,
         V1.sd=0.01,V2.sd=0.1,Cl1.sd=0.01,Cl2.sd=0.01)
#>         Parameter     Estimate      Std.err
#> Vdss         Vdss 55.000000000 1.004988e-01
#> V1             V1  5.000000000 1.000000e-02
#> V2             V2 50.000000000 1.000000e-01
#> Cl1           Cl1  3.500000000 1.000000e-02
#> Cl2           Cl2  2.500000000 1.000000e-02
#> k10           k10  0.700000000 2.441311e-03
#> k12           k12  0.500000000 2.236068e-03
#> k21           k21  0.050000000 2.236068e-04
#> alpha       alpha  1.221343022 3.765020e-03
#> beta         beta  0.028656978 9.280865e-05
#> t_alpha   t_alpha  0.567528670 1.749514e-03
#> t_beta     t_beta 24.187727779 7.833451e-02
#> True_A     True_A  0.196421016 4.007910e-04
#> True_B     True_B  0.003578984 2.157918e-05
#> Frac_A     Frac_A  0.982105079 1.140066e-04
#> Frac_B     Frac_B  0.017894921 1.140066e-04