Compute Deltas

Compute Deltas

Usage

compute_deltas(
  data,
  qt_col = QT,
  qtbl_col = QTBL,
  rr_col = RR,
  rrbl_col = RRBL,
  hr_col = HR,
  hrbl_col = HRBL,
  qtcf_col = QTCF,
  qtcfbl_col = QTCFBL,
  qtcb_col = QTCB,
  qtcbbl_col = QTCBBL
)

Arguments

data

A data frame containing C-QT analysis dataset

qt_col

An unquoted column name for QT measurements

qtbl_col

An unquoted column name for baseline QT measurements

rr_col

An unquoted column name for RR measurements

rrbl_col

An unquoted column name for baseline RR measurements

hr_col

An unquoted column name for HR measurements, HR by default

hrbl_col

An unquoted column name for baseline HR measurements, HRBL by default

qtcf_col

An unquoted column name for QTCF measurements, QTCF by default

qtcfbl_col

An unquoted column name for baseline QTCF measurements, QTCFBL by default

qtcb_col

An unquoted column name for QTCB measurements, QTCB by default

qtcbbl_col

An unquoted column name for baseline QTCB measurements, QTCBBL by default

Value

A data frame with deltaPARAM columns added

Examples

compute_deltas(compute_qtcb_qtcf(cqtkit_data_verapamil))
#> # A tibble: 643 × 30
#>       ID TRTG   DOSE DOSEU DOSEF  NTLD TAFD   CONC CONCU    RR  RRBL    HR  HRBL
#>    <dbl> <fct> <dbl> <chr> <fct> <dbl> <chr> <dbl> <chr> <dbl> <dbl> <dbl> <dbl>
#>  1  1001 Plac…     0 mg    0 mg    0.5 0.5 …     0 NA     968   851   62.0  70.5
#>  2  1002 Plac…     0 mg    0 mg    0.5 0.5 …     0 NA    1097. 1193.  54.7  50.3
#>  3  1003 Plac…     0 mg    0 mg    0.5 0.5 …     0 NA    1026.  923.  58.5  65.2
#>  4  1004 Plac…     0 mg    0 mg    0.5 0.5 …     0 NA     862.  883.  69.6  68.0
#>  5  1005 Plac…     0 mg    0 mg    0.5 0.5 …     0 NA    1060. 1126.  56.6  53.3
#>  6  1006 Plac…     0 mg    0 mg    0.5 0.5 …     0 NA     998   999   60.2  60.2
#>  7  1007 Plac…     0 mg    0 mg    0.5 0.5 …     0 NA     919.  909   65.4  66.1
#>  8  1008 Plac…     0 mg    0 mg    0.5 0.5 …     0 NA     827.  991   72.5  60.6
#>  9  1009 Plac…     0 mg    0 mg    0.5 0.5 …     0 NA     872.  798.  68.9  75.3
#> 10  1010 Plac…     0 mg    0 mg    0.5 0.5 …     0 NA    1070. 1071   56.1  56.0
#> # ℹ 633 more rows
#> # ℹ 17 more variables: HRBLM <dbl>, deltaHRBL <dbl>, QT <dbl>, QTBL <dbl>,
#> #   QTCB <dbl>, QTCBBL <dbl>, QTCBBLM <dbl>, deltaQTCBBL <dbl>, QTCF <dbl>,
#> #   QTCFBL <dbl>, QTCFBLM <dbl>, deltaQTCFBL <dbl>, deltaQTCB <dbl>,
#> #   deltaQTCF <dbl>, deltaRR <dbl>, deltaHR <dbl>, deltaQT <dbl>