Compute ECG Parameter Summary — compute_ecg_param

Generates a tibble of summary of QTc, dQTc and ddQTc over time stratified by dose.

Usage

compute_ecg_param_summary(
  data,
  ntime_col,
  dose_col,
  ecg_param_col,
  deltaecg_param_col,
  group_col = NULL,
  reference_dose = NULL,
  conf_int = 0.95
)

Arguments

data: A data frame containing C-QT analysis dataset
ntime_col: An unquoted column name for nominal time data
dose_col: An unquoted column name for dose data
ecg_param_col: An unquoted column name for QTc measurements
deltaecg_param_col: An unquoted column name for deltaQTc measurements
group_col: An unquoted column name for additional grouping column
reference_dose: Reference dose value for comparison calculations
conf_int: Numeric confidence interval level (default: 0.9)

Value

A tibble with mean QTc, deltaQTc, and optionally delta-delta QTc values with confidence intervals, stratified by dose and time

Examples

data_proc <- cqtkit_data_verapamil %>% preprocess()

compute_ecg_param_summary(data_proc, NTLD, DOSEF, QTCF, deltaQTCF)
#> # A tibble: 30 × 10
#>    dose   time     n mean_ecg ecg_low ecg_high group mean_decg decg_low
#>    <fct> <dbl> <int>    <dbl>   <dbl>    <dbl> <chr>     <dbl>    <dbl>
#>  1 0 mg    0.5    22     387.    380.     394. 0 mg      -8.28   -11.1 
#>  2 0 mg    1      22     390.    383.     398. 0 mg      -5.43    -8.55
#>  3 0 mg    1.5    22     390.    383.     398. 0 mg      -5.42    -8.42
#>  4 0 mg    2      22     393.    386.     401. 0 mg      -2.28    -4.60
#>  5 0 mg    2.5    22     392.    384.     400. 0 mg      -4.07    -8.37
#>  6 0 mg    3      22     390.    382.     398. 0 mg      -5.85    -9.48
#>  7 0 mg    3.5    22     386.    380.     393. 0 mg      -9.42   -13.5 
#>  8 0 mg    4      21     388.    380.     396. 0 mg      -7.73   -11.7 
#>  9 0 mg    5      22     386.    378.     394. 0 mg      -9.39   -13.8 
#> 10 0 mg    6      22     388.    380.     396. 0 mg      -7.41   -13.5 
#> # ℹ 20 more rows
#> # ℹ 1 more variable: decg_high <dbl>