Compute PK Parameters — compute_pk

Generates PK parameters Cmax and Tmax for exposure predictions.

Usage

compute_pk_parameters(
  data,
  id_col,
  dose_col,
  conc_col,
  ntime_col,
  group_col = NULL
)

Arguments

data: A data frame containing C-QT analysis dataset
id_col: An unquoted column name for subject ID
dose_col: An unquoted column name for dose measurements
conc_col: An unquoted column name for drug concentration measurements
ntime_col: An unquoted column name for nominal times
group_col: An unquoted column name for additional grouping variable

Value

A tibble with PK summary statistics by group: N, Tmax (median/min/max), and Cmax (geometric mean, CV%, median/min/max)

Examples

compute_pk_parameters(
  preprocess(cqtkit_data_verapamil) %>% dplyr::filter(DOSE != 0),
  ID,
  DOSE,
  CONC,
  NTLD)
#> # A tibble: 1 × 10
#>   group     N Tmax_median Tmax_max Tmax_min Cmax_gm Cmax_cv Cmax_median Cmax_max
#>   <dbl> <int>       <dbl>    <dbl>    <dbl>   <dbl>   <dbl>       <dbl>    <dbl>
#> 1   120    21           1        2      0.5    114.    57.0         102      368
#> # ℹ 1 more variable: Cmax_min <dbl>