Tabulate ECG Parameter Summary — tabulate_ecg_param

Generates a gt table of summary of QTc, dQTc and ddQTc over time stratified by dose.

Usage

tabulate_ecg_param_summary(
  data,
  ntime_col,
  dose_col,
  ecg_param_col,
  delta_ecg_param_col,
  ecg_param_name,
  unit = "",
  group_col = NULL,
  reference_dose = NULL,
  ecg_param_conf_int = 0.95,
  delta_ecg_param_conf_int = 0.9,
  decimals = 2,
  row_group_label = NULL,
  time_label = "Time (hr)",
  title = NULL,
  ...
)

Arguments

data: A data frame containing C-QT analysis dataset
ntime_col: An unquoted column name for nominal time data
dose_col: An unquoted column name for dose data
ecg_param_col: An unquoted column name for QTc measurements
delta_ecg_param_col: An unquoted column name for deltaQTc measurements
ecg_param_name: A string of the ecg parameter being summarized, e.g. QTc or HR
unit: A string of the unit for ecg_parameter
group_col: An unquoted column name for additional grouping column
reference_dose: A reference dose value for comparison calculations
ecg_param_conf_int: Confidence interval for QTc summary stats default 95%
delta_ecg_param_conf_int: Confidence interval for dQTc summary stats default 90%
decimals: Number of decimals to fmt the table to default is 2, N column is 0
row_group_label: Optional label for the dose/dose + group column
time_label: A string label for the time column (default: "Time (hr)")
title: Optional title for the table, it will be wrapped in gt::md()
...: Optional arguments for gt::tab_options

Value

A gt table with mean ECG parameters (QTc, deltaQTc, delta-delta QTc) and confidence intervals by dose and time

Examples

data_proc <- cqtkit_data_verapamil %>% preprocess()
tabulate_ecg_param_summary(
 data_proc,
 NTLD,
 DOSEF,
 QTCF,
 deltaQTCF,
 "QTc",
 "ms",
 reference_dose = "0 mg")


  
      
      
        Baseline Corrected
      
      
        Baseline and Placebo
      
    

      Time (hr)
      N
      
        Observed QTc (ms)
      
      
        QTc (ms)
      
      
        Corrected QTc (ms)
      
    
Mean
      95% CI
      Mean
      90% CI
      Mean
      90% CI
    
0 mg
0.50
22
387.48
[380.47, 394.50]
−8.28
[−10.64, −5.92]
—
[—, —]
1.00
22
390.33
[382.70, 397.97]
−5.43
[−8.01, −2.84]
—
[—, —]
1.50
22
390.34
[383.03, 397.65]
−5.42
[−7.90, −2.93]
—
[—, —]
2.00
22
393.48
[385.74, 401.21]
−2.28
[−4.20, −0.36]
—
[—, —]
2.50
22
391.69
[383.77, 399.62]
−4.07
[−7.62, −0.51]
—
[—, —]
3.00
22
389.91
[382.10, 397.71]
−5.85
[−8.86, −2.85]
—
[—, —]
3.50
22
386.34
[379.56, 393.11]
−9.42
[−12.80, −6.05]
—
[—, —]
4.00
21
388.02
[379.94, 396.09]
−7.73
[−10.98, −4.49]
—
[—, —]
5.00
22
386.37
[378.32, 394.43]
−9.39
[−13.01, −5.77]
—
[—, —]
6.00
22
388.35
[380.22, 396.47]
−7.41
[−12.47, −2.36]
—
[—, —]
7.00
22
386.40
[378.56, 394.25]
−9.36
[−14.04, −4.68]
—
[—, —]
8.00
22
386.27
[378.05, 394.48]
−9.49
[−13.83, −5.16]
—
[—, —]
12.00
22
382.67
[375.20, 390.15]
−13.09
[−16.89, −9.29]
—
[—, —]
14.00
22
383.61
[376.01, 391.22]
−12.15
[−15.53, −8.77]
—
[—, —]
24.00
21
390.77
[382.89, 398.65]
−5.00
[−9.06, −0.94]
—
[—, —]
120 mg
0.50
21
389.86
[381.92, 397.80]
−5.86
[−8.22, −3.51]
2.41
[−0.84, 5.67]
1.00
21
395.46
[388.58, 402.33]
−0.27
[−3.32, 2.78]
5.15
[1.25, 9.06]
1.50
21
391.53
[383.99, 399.06]
−4.20
[−7.34, −1.06]
1.21
[−2.70, 5.13]
2.00
21
397.24
[389.10, 405.39]
1.52
[−1.72, 4.76]
3.80
[0.12, 7.48]
2.50
21
396.74
[388.41, 405.06]
1.01
[−2.92, 4.94]
5.07
[−0.10, 10.25]
3.00
21
393.10
[384.61, 401.59]
−2.63
[−5.90, 0.65]
3.23
[−1.11, 7.57]
3.50
21
389.82
[381.20, 398.44]
−5.91
[−9.74, −2.08]
3.52
[−1.47, 8.50]
4.00
21
391.84
[382.88, 400.80]
−3.89
[−7.47, −0.30]
3.85
[−0.88, 8.57]
5.00
21
389.49
[381.59, 397.39]
−6.24
[−10.59, −1.89]
3.15
[−2.38, 8.67]
6.00
21
390.75
[383.08, 398.42]
−4.98
[−9.87, −0.08]
2.44
[−4.44, 9.31]
7.00
21
389.95
[382.66, 397.24]
−5.78
[−10.43, −1.12]
3.58
[−2.87, 10.03]
8.00
21
388.72
[381.07, 396.37]
−7.01
[−11.50, −2.51]
2.49
[−3.61, 8.58]
12.00
21
385.63
[378.04, 393.22]
−10.10
[−14.46, −5.74]
2.99
[−2.66, 8.64]
14.00
21
387.11
[379.37, 394.84]
−8.62
[−12.51, −4.73]
3.53
[−1.51, 8.56]
24.00
21
388.86
[381.98, 395.75]
−6.86
[−10.62, −3.11]
−1.86
[−7.26, 3.54]

					Baseline Corrected		Baseline and Placebo
	Time (hr)	N	Observed QTc (ms)		QTc (ms)		Corrected QTc (ms)
	Time (hr)	N	Mean	95% CI	Mean	90% CI	Mean	90% CI
0 mg	0.50	22	387.48	[380.47, 394.50]	−8.28	[−10.64, −5.92]	—	[—, —]
	1.00	22	390.33	[382.70, 397.97]	−5.43	[−8.01, −2.84]	—	[—, —]
	1.50	22	390.34	[383.03, 397.65]	−5.42	[−7.90, −2.93]	—	[—, —]
	2.00	22	393.48	[385.74, 401.21]	−2.28	[−4.20, −0.36]	—	[—, —]
	2.50	22	391.69	[383.77, 399.62]	−4.07	[−7.62, −0.51]	—	[—, —]
	3.00	22	389.91	[382.10, 397.71]	−5.85	[−8.86, −2.85]	—	[—, —]
	3.50	22	386.34	[379.56, 393.11]	−9.42	[−12.80, −6.05]	—	[—, —]
	4.00	21	388.02	[379.94, 396.09]	−7.73	[−10.98, −4.49]	—	[—, —]
	5.00	22	386.37	[378.32, 394.43]	−9.39	[−13.01, −5.77]	—	[—, —]
	6.00	22	388.35	[380.22, 396.47]	−7.41	[−12.47, −2.36]	—	[—, —]
	7.00	22	386.40	[378.56, 394.25]	−9.36	[−14.04, −4.68]	—	[—, —]
	8.00	22	386.27	[378.05, 394.48]	−9.49	[−13.83, −5.16]	—	[—, —]
	12.00	22	382.67	[375.20, 390.15]	−13.09	[−16.89, −9.29]	—	[—, —]
	14.00	22	383.61	[376.01, 391.22]	−12.15	[−15.53, −8.77]	—	[—, —]
	24.00	21	390.77	[382.89, 398.65]	−5.00	[−9.06, −0.94]	—	[—, —]
120 mg	0.50	21	389.86	[381.92, 397.80]	−5.86	[−8.22, −3.51]	2.41	[−0.84, 5.67]
	1.00	21	395.46	[388.58, 402.33]	−0.27	[−3.32, 2.78]	5.15	[1.25, 9.06]
	1.50	21	391.53	[383.99, 399.06]	−4.20	[−7.34, −1.06]	1.21	[−2.70, 5.13]
	2.00	21	397.24	[389.10, 405.39]	1.52	[−1.72, 4.76]	3.80	[0.12, 7.48]
	2.50	21	396.74	[388.41, 405.06]	1.01	[−2.92, 4.94]	5.07	[−0.10, 10.25]
	3.00	21	393.10	[384.61, 401.59]	−2.63	[−5.90, 0.65]	3.23	[−1.11, 7.57]
	3.50	21	389.82	[381.20, 398.44]	−5.91	[−9.74, −2.08]	3.52	[−1.47, 8.50]
	4.00	21	391.84	[382.88, 400.80]	−3.89	[−7.47, −0.30]	3.85	[−0.88, 8.57]
	5.00	21	389.49	[381.59, 397.39]	−6.24	[−10.59, −1.89]	3.15	[−2.38, 8.67]
	6.00	21	390.75	[383.08, 398.42]	−4.98	[−9.87, −0.08]	2.44	[−4.44, 9.31]
	7.00	21	389.95	[382.66, 397.24]	−5.78	[−10.43, −1.12]	3.58	[−2.87, 10.03]
	8.00	21	388.72	[381.07, 396.37]	−7.01	[−11.50, −2.51]	2.49	[−3.61, 8.58]
	12.00	21	385.63	[378.04, 393.22]	−10.10	[−14.46, −5.74]	2.99	[−2.66, 8.64]
	14.00	21	387.11	[379.37, 394.84]	−8.62	[−12.51, −4.73]	3.53	[−1.51, 8.56]
	24.00	21	388.86	[381.98, 395.75]	−6.86	[−10.62, −3.11]	−1.86	[−7.26, 3.54]