Whittemore-Halpern scores for allele-sharing

Whittemore-Halpern scores for allele-sharing

Usage

whscore(allele, type)

Arguments

allele

a matrix of alleles of affected pedigree members.

type

0 = pairs, 1 = all.

Value

The returned value is the value of score statistic.

Details

Allele sharing score statistics.

Note

adapted from GENEHUNTER.

References

Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES (1996). “Parametric and nonparametric linkage analysis: a unified multipoint approach.” Am J Hum Genet, 58(6), 1347-63.

Whittemore AS, Halpern J (1994). “A class of tests for linkage using affected pedigree members.” Biometrics, 50(1), 118-27.

Whittemore AS, Halpern J (1994). “Probability of gene identity by descent: computation and applications.” Biometrics, 50(1), 109-17.

Author

Leonid Kruglyak, Jing Hua Zhao

Examples

if (FALSE) { # \dontrun{
c<-matrix(c(1,1,1,2,2,2),ncol=2)
whscore(c,type=1)
whscore(c,type=2)
} # }